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Basic research基礎研究
当研究室では、最新の空間解析・単一細胞解析プラットフォームなど先端オミクス解析技術を活用し、専門家のサポートのもとで、大学院生が各自の関心に沿った研究テーマを主体的に推進しています。
リンパ腫研究
リンパ腫グループでは最新鋭の機器を用いたトランスレーショナルリサーチを行っています。B細胞リンパ腫を研究対象としたラボは国内でも少なく、当グループの保有する研究サンプルは国内でも最大規模となっています。この貴重な臨床サンプルを用いて、分子生物学的メカニズム解明と臨床応用可能なバイオマーカー開発を目指しています。大規模データ解析が中心となる点は難しく思われるかもしれませんが、バイオインフォマティシャンも常駐しており、初心者でも解析可能な環境整備を進めています。
このように臨床サンプルを用いた大規模マルチオミクス解析を、自施設のみならず国内外の研究機関と連携しながら研究を進める体制も整っており、充実した研究体制となっています。少しでもご興味がある方はぜひ私たちと一緒にリンパ腫研究を行いましょう!
CAR-T MM研究
多発性骨髄腫を対象とした、シングルセル解析や空間的解析を行っています。また共同研究室と連携し、BCMA-CAR-T細胞療法を受けた骨髄腫症例を対象として、時空間的解析を進めています。これらの手法は他のCAR-T細胞療法への展開も期待されており、多発性骨髄腫を対象としたトランスレーショナルリサーチに関心のある方の参加を歓迎します。
軟部肉腫研究
軟部肉腫は希少疾患であり、治療法は限られています。症例間のみならず、症例内での多様性・不均一性が著しく、研究上の課題とされています。私たちは、この不均一性を加味したマルチオミクス解析により予後因子の検索、治療法の開発を目指しています。
Clinical research臨床研究
臨床研究では、実臨床で得られた臨床情報や大規模データを用いたリアルワールドデータ解析や、新規治療を用いた臨床試験や治験などを積極的に行っています。各診療科や新医療研究開発センターなどとの連携体制で、多様なアプローチが可能です。
リアルワールドデータ解析
がんゲノム医療での臨床経験や、がん遺伝子パネル検査登録データ（国立がん研究センター・がんゲノム情報管理センター（C-CAT）データベース）を利活用した、臨床研究を積極的に進めています。ゲノム医療総合推進センターのサポートにより、各種データへのアクセスが可能です。
医師主導臨床試験、治験
当教室では臓器横断的な治験・臨床試験に数多く参加しています。主にがん遺伝子パネル検査で得られたゲノム情報を基に、新規薬剤を用いた治験・臨床試験に参加しており、患者さんに先端医療を届ける窓口となります。
現在、先進医療として「ロルラチニブ耐性・不忍容ALK 融合遺伝子陽性肺がんに対する ギルテリチニブ療法の安全性・有効性を検討する第Ⅰ相試験（担当：腫瘍センター長 市原 英基）」を実施しています。ロルラチニブに耐性となったALK肺がんの治療選択肢は限られています。そこで私たちは、AML治療薬であるFLT3阻害薬「ギルテリチニブ」に着目し、前臨床研究により、本薬が強力なALK阻害作用を有することを確認しました。この成果を臨床に還元する目的に、本試験を実施しています。今後は第II相試験や公知申請による薬事承認を目指します。
既存の治療に抵抗性を示す患者さんに新たな希望を届けるため、アカデミア主導の創薬研究として非常に重要なステップです。-CAR-T細胞療法を受けた骨髄腫症例を対象として、時空間的解析を進めています。これらの手法は他のCAR-T細胞療法への展開も期待されており、多発性骨髄腫を対象としたトランスレーショナルリサーチに関心のある方の参加を歓迎します。
ゲノム医療総合推進センター
ゲノム医療総合推進センターでは、ハイスループットラボを有し、1細胞（シングルセル）RNA解析プラットフォーム、1細胞（シングルセル）DNA/プロテイン解析プラットフォームに加え、空間マルチオミクス解析プラットフォーム（GeoMx, CosMx）など、最先端のマルチオミクス解析設備が備わってます。これらの機器に加えて、ハイスループットデータ解析をサポートするバイオインフォマティシャンが2名常勤スタッフとして在籍し、世界レベルのマルチオミックス解析が可能です。
ゲノム医療総合推進センターの詳細については、公式ホームページをご覧ください。
バイオバンク
バイオバンクは、病院内・学内のみならず、企業を含む様々な施設で行われる研究開発の支援を2015年より行ってきました。がんや自己免疫疾患など様々な疾患のヒト生体試料の保管・提供を行っているほか、多施設からの前向き収集の支援も行っています。幅広い研究開発を支えるインフラとして、利用しやすい施設であること、および高品質な試料を提供することに努めてきました。これからも、時代に合わせて変化をしながら、また学内の他施設や関連部署と連携をしながら、未来の医療の創出を支える組織であり続けます。
バイオバンクのホームページの詳細については、公式ホームページをご覧ください。
Publications業績
2025
Real-World Data of Comprehensive Cancer Genomic Profiling Tests Performed in the Routine Clinical Setting in Sarcoma.
Eiji Nakata,Daisuke Ennishi,Tatsunori Osone,Kiichiro Ninomiya,Shuta Tomida,Takuto Itano,Tomohiro Fujiwara,Toshiyuki Kunisada,Naoyuki Ida,Hideki Yamamoto,Mashu Futagawa,Tatsunori Shimoi,Hiroyuki Yanai,Akira Hirasawa,Shinichi Toyooka,Masahiro Tabata,Toshifumi Ozaki.
Cancer medicine. 2025. 14(15):e71098
Single-cell and spatial transcriptomic characterization of pulmonary pleomorphic carcinoma.
Atsushi Matsuoka,Kazuhiko Shien,Shuta Tomida,Masayoshi Ohki,Kazuya Hisamatsu,Ryota Fujiwara,Kosei Ishimura,Ryunosuke Fujii,Tomoaki Higashihara,Naohiro Hayashi,Kazuhiro Okada,Ryo Yoshichika,Fumiaki Mukohara,Mao Yoshikawa,Yuma Fukumoto,Ken Suzawa,Yasuaki Tomioka,Shin Tanaka,Kentaroh Miyoshi,Mikio Okazaki,Seiichiro Sugimoto,Yusuke Otani,Atsushi Tanaka,Hirofumi Inoue,Yosuke Togashi,Hidetaka Yamamoto,Daisuke Ennishi,Shinichi Toyooka.
Communications biology. 2025. 8(1):1773
Close Spatial Interactions between Cancer Cells and Cancer-Associated Fibroblasts Suppress Antitumor Immunity.
Yuto Naoi,Yumi Inukai,Tomoka Izumikawa,Joji Nagasaki,Takamasa Ishino,Youki Ueda,Yin Min Thu,Miho Fujiwara,Takahiro Baba,Go Makimoto,Ken Suzawa,Kazuhiro Okada,Ken-Ichi Yamamoto,Masakiyo Sakaguchi,Shuta Tomida,Yoshinobu Maeda,Shinichi Toyooka,Mizuo Ando,Yosuke Togashi.
Cancer immunology research. 2025. 13(9):1471-1484
Colony-Stimulating Factor-1 Receptor Inhibitor Augments Osimertinib-Induced Antitumor Immunity via Suppression of Macrophages in Lung Cancer Harboring EGFR Mutation.
Sachi Okawa,Shuta Tomida,Tadahiro Kuribayashi,Jun Nishimura,Takamasa Nakasuka,Atsuko Hirabae,Naofumi Hara,Hirofumi Inoue,Go Makimoto,Kiichiro Ninomiya,Kammei Rai,Eiki Ichihara,Katuyuki Hotta,Masahiro Tabata,Yoshinobu Maeda,Katsuyuki Kiura,Kadoaki Ohashi.
Molecular cancer therapeutics. 2025. 24(11):1763-1774
Cytomegalovirus reactivation in patients with large B-cell lymphoma treated with chimeric antigen receptor T-cell therapy.
Kenta Hayashino,Keisuke Seike,Taro Masunari,Risa Hashida,Satoshi Oka,Yuki Fujiwara,Toshiki Terao,Wataru Kitamura,Hiroki Kobayashi,Chihiro Kamoi,Takumi Kondo,Hideaki Fujiwara,Noboru Asada,Daisuke Ennishi,Keiko Fujii,Nobuharu Fujii,Yoshinobu Maeda.
International journal of hematology. 2025. 122(5):689-699
Distinct age-related effects of homologous recombination deficiency on genomic profiling and treatment efficacy in gastric cancer.
Yoshie Maki,Yoshiyasu Kono,Toshiki Ozato,Hideki Yamamoto,Akira Hirasawa,Daisuke Ennishi,Shuta Tomida,Shinichi Toyooka,Kenta Hamada,Masaya Iwamuro,Seiji Kawano,Motoyuki Otsuka.
Journal of gastroenterology. 2025. 60(10):1232-1241
Genomic landscape and clinical impact of homologous recombination repair gene mutation in small bowel adenocarcinoma.
Toshiki Ozato,Yoshiyasu Kono,Shigeru Horiguchi,Koichiro Tsutsumi,Hideki Yamamoto,Akira Hirasawa,Daisuke Ennishi,Shuta Tomida,Shinichi Toyooka,Motoyuki Otsuka.
European journal of cancer. 2025. 220:115401
The Involvement of PI3K-Akt Signaling in the Clinical and Pathological Findings of Idiopathic Multicentric Castleman Disease-Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, and Organomegaly and Not Otherwise Specified Subtypes.
Tomoka Haratake,Midori Filiz Nishimura,Asami Nishikori,Michael V Gonzalez,Daisuke Ennishi,You Cheng Lai,Sayaka Ochi,Manaka Tsunoda,David C Fajgenbaum,Frits van Rhee,Shuji Momose,Yasuharu Sato.
Modern pathology. 2025. 38(8):100782
Genomic Differences and Distinct TP53 Mutation Site-Linked Chemosensitivity in Early- and Late-Onset Gastric Cancer.
Tomohiro Kamio,Yoshiyasu Kono,Kensuke Hirosuna,Toshiki Ozato,Hideki Yamamoto,Akira Hirasawa,Daisuke Ennishi,Shuta Tomida,Shinichi Toyooka,Motoyuki Otsuka.
Cancer medicine. 2025. 14(8):e70793
Myelodysplastic neoplasms with repeating TAFRO syndrome-like symptoms.
Kenta Hayashino,Nobuharu Fujii,Tomohiro Nagano,Daisuke Ikeda,Kanako Fujiwara,Risa Hashida,Wataru Kitamura,Hiroki Kobayashi,Takumi Kondo,Keisuke Seike,Hideaki Fujiwara,Noboru Asada,Daisuke Ennishi,Keiko Fujii,Ken-Ichi Matsuoka,Yoshinobu Maeda.
International journal of hematology. 2025. 121(5):706-711
Single-cell and spatial characterization of plasmablast-like lymphoma cells in primary central nervous system lymphoma.
Hiroki Kobayashi,Ryota Chijimatsu,Yusuke Naoi,Yoshihiro Otani,Ryo Mizuta,Kentaro Fujii,Joji Ishida,Hiroyuki Murakami,Hideki Ujiie,Kazuhiro Ikeuchi,Tomohiro Urata,Keisuke Seike,Hideaki Fujiwara,Noboru Asada,Nobuharu Fujii,Ken-Ichi Matsuoka,Yasuharu Sato,Yoshinobu Maeda,Daisuke Ennishi.
Blood neoplasia. 2025. 2(1):100058
Severe hypophosphatemia following idecabtagene vicleucel regardless of the severity of cytokine release syndrome.
Kenta Hayashino,Wataru Kitamura,Nobuharu Fujii,Toshiki Terao,Hiroki Kobayashi,Chihiro Kamoi,Takumi Kondo,Keisuke Seike,Hideaki Fujiwara,Noboru Asada,Daisuke Ennishi,Keiko Fujii,Yoshinobu Maeda.
Cytotherapy. 2025. 27(4):516-521
2024
Outcomes of allogeneic SCT versus tisagenlecleucel in patients with R/R LBCL and poor prognostic factors.
Kenta Hayashino,Toshiki Terao,Hisakazu Nishimori,Wataru Kitamura,Hiroki Kobayashi,Chihiro Kamoi,Keisuke Seike,Hideaki Fujiwara,Noboru Asada,Daisuke Ennishi,Keiko Fujii,Nobuharu Fujii,Ken-Ichi Matsuoka,Yoshinobu Maeda.
International journal of hematology. 2024. 121(2):232-243
Response to Imatinib in a Patient With Gastric Adenocarcinoma With KIT Q556_K558 In-Frame Deletion: A Case Report.
Kiichiro Ninomiya,Daisuke Ennishi,Kunio Okamoto,Midori Ando,Satoko Nakamura,Shuta Tomida,Yoshiyuki Ayada,Go Makimoto,Eiki Ichihara,Natsuko Okita,Shinichi Toyooka,Yoshinobu Maeda,Masahiro Tabata.
JCO precision oncology. 2024. 8:e2400228
Soluble immune checkpoint factors reflect exhaustion of antitumor immunity and response to PD-1 blockade.
Hidetoshi Hayashi,Kenji Chamoto,Ryusuke Hatae,Takashi Kurosaki,Yosuke Togashi,Kazuya Fukuoka,Megumi Goto,Yasutaka Chiba,Shuta Tomida,Takayo Ota,Koji Haratani,Takayuki Takahama,Junko Tanizaki,Takeshi Yoshida,Tsutomu Iwasa,Kaoru Tanaka,Masayuki Takeda,Tomoko Hirano,Hironori Yoshida,Hiroaki Ozasa,Yuichi Sakamori,Kazuko Sakai,Keiko Higuchi,Hitoshi Uga,Chihiro Suminaka,Toyohiro Hirai,Kazuto Nishio,Kazuhiko Nakagawa,Tasuku Honjo.
The Journal of clinical investigation. 2024. 134(7):e168318
Recent updates on treatment options for primary follicular lymphoma of the gastrointestinal tract.
Masaya Iwamuro,Takehiro Tanaka,Daisuke Ennishi,Motoyuki Otsuka.
Expert review of gastroenterology & hepatology. 2024. 18(7):367-375
Safety and efficacy of acalabrutinib and obinutuzumab in treatment-naive chronic lymphocytic leukemia: a Japanese phase 1 study.
Jun Takizawa,Takanori Teshima,Daisuke Ennishi,Satoshi Ichikawa,Ritsuro Suzuki,Akira Kojima,Yusuke Takahashi,Nobuya Hayashi,Hisashi Kawasumi,Kosho Murayama,Patricia Cheung,Toshio Kawata,Koji Izutsu.
Leukemia & lymphoma. 2024. 65(11):1586-1594
Combination of reduced post‐transplant cyclophosphamide and early tacrolimus initiation increases the incidence of chronic graft‐versus‐host disease in human leukocyte antigen‐haploidentical peripheral blood stem‐cell transplantation.
Toshiki Terao,Takumi Kondo,Makoto Nakamura,Hiroki Takasuka,Hideaki Fujiwara,Noboru Asada,Daisuke Ennishi,Hisakazu Nishimori,Keiko Fujii,Nobuharu Fujii,Yoshinobu Maeda,Ken‐ichi Matsuoka.
eJHaem. 2024. 5(4):810-814
Understanding the intrinsic biology of diffuse large B-cell lymphoma: recent advances and future prospects.
Yusuke Naoi,Daisuke Ennishi.
International journal of hematology. 2024. 121(3):321-325
Endoscopic manifestation of intestinal transplant-associated microangiopathy after stem cell transplantation.
Masaya Iwamuro,Daisuke Ennishi,Nobuharu Fujii,Ken-Ichi Matsuoka,Takehiro Tanaka,Toshihiro Inokuchi,Sakiko Hiraoka,Motoyuki Otsuka.
BMC gastroenterology. 2024. 24(1):140
Topical application of activator protein-1 inhibitor T-5224 suppresses inflammation and improves skin barrier function in a murine atopic dermatitis-like dermatitis.
Minori Sasakura,Hitoshi Urakami,Kota Tachibana,Kenta Ikeda,Ken-Ichi Hasui,Yoshihiro Matsuda,Ko Sunagawa,Daisuke Ennishi,Shuta Tomida,Shin Morizane.
Allergology international. 2024. 73(2):323-331
Chimeric antigen receptor T-cell therapy after COVID-19 in refractory high-grade B-cell lymphoma.
Kenta Hayashino,Keisuke Seike,Kanako Fujiwara,Kaho Kondo,Chisato Matsubara,Toshiki Terao,Wataru Kitamura,Chihiro Kamoi,Hideaki Fujiwara,Noboru Asada,Hisakazu Nishimori,Daisuke Ennishi,Keiko Fujii,Nobuharu Fujii,Ken-Ichi Matsuoka,Yoshinobu Maeda.
International journal of hematology. 2024. 119(4):459-464
Transcriptome analysis of the cytokine storm-related genes among the subtypes of idiopathic multicentric Castleman disease.
Asami Nishikori,Midori Filiz Nishimura,Shuta Tomida,Ryota Chijimatsu,Himawari Ueta,You Cheng Lai,Yuri Kawahara,Yudai Takeda,Sayaka Ochi,Tomoka Haratake,Daisuke Ennishi,Naoya Nakamura,Shuji Momose,Yasuharu Sato.
Journal of Clinical and Experimental Hematopathology. 2024. 64(4):297-306
A Learning Program for Treatment Recommendations by Molecular Tumor Boards and Artificial Intelligence.
Kuniko Sunami,Yoichi Naito,Yusuke Saigusa,Toraji Amano,Daisuke Ennishi,Mitsuho Imai,Hidenori Kage,Masashi Kanai,Hirotsugu Kenmotsu,Keigo Komine,Takafumi Koyama,Takahiro Maeda,Sachi Morita,Daisuke Sakai,Makoto Hirata,Mamoru Ito,Toshiyuki Kozuki,Hiroyuki Sakashita,Hidehito Horinouchi,Yusuke Okuma,Atsuo Takashima,Toshio Kubo,Shuichi Hironaka,Yoshihiko Segawa,Yoshihiro Yakushijin,Hideaki Bando,Akitaka Makiyama,Tatsuya Suzuki,Ichiro Kinoshita,Shinji Kohsaka,Yuichiro Ohe,Chikashi Ishioka,Kouji Yamamoto,Katsuya Tsuchihara,Takayuki Yoshino.
JAMA oncology. 2024. 10(1):95-102
2023
Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array.
Yasuaki Tomioka,Seiichiro Sugimoto,Haruchika Yamamoto,Shuta Tomida,Toshio Shiotani,Shin Tanaka,Kazuhiko Shien,Ken Suzawa,Kentaroh Miyoshi,Shinji Otani,Hiromasa Yamamoto,Mikio Okazaki,Masaomi Yamane,Shinichi Toyooka.
Scientific reports. 2023. 13(1):8192
Persistent alteration of the skin microbiome in patients with skin rash after receiving EGFR inhibitor treatment.
Atsuko Ashida,Shuta Tomida,Tokuro Iwabuchi,Yuki Sato,Yukiko Kiniwa,Ryuhei Okuyama.
Experimental dermatology. 2023. 32(5):671-677
Distribution and clinical impact of molecular subtypes with Dark Zone signature of DLBCL in a Japanese real-world study.
Tomohiro Urata,Yusuke Naoi,Aixiang Jiang,Merrill Boyle,Kazutaka Sunami,Toshi Imai,Yuichiro Nawa,Yasushi Hiramatsu,Kazuhiko Yamamoto,Soichiro Fujii,Isao Yoshida,Tomofumi Yano,Ryota Chijimatsu,Hiroyuki Murakami,Kazuhiro Ikeuchi,Hiroki Kobayashi,Katsuma Tani,Hideki Ujiie,Hirofumi Inoue,Shuta Tomida,Akira Yamamoto,Takumi Kondo,Hideaki Fujiwara,Noboru Asada,Hisakazu Nishimori,Keiko Fujii,Nobuharu Fujii,Ken-Ichi Matsuoka,Keisuke Sawada,Shuji Momose,Jun-Ichi Tamaru,Asami Nishikori,Yasuharu Sato,Tadashi Yoshino,Yoshinobu Maeda,David W Scott,Daisuke Ennishi.
Blood advances. 2023. 7(24):7459-7470
Feasibility of Flow Cytometry Analysis of Gastrointestinal Tract-Residing Lymphocytes in Hematopoietic Stem Cell Transplant Recipients.
Masaya Iwamuro,Takumi Kondo,Daisuke Ennishi,Nobuharu Fujii,Ken-Ichi Matsuoka,Takahide Takahashi,Araki Hirabata,Takehiro Tanaka,Fumio Otsuka,Yoshinobu Maeda,Hiroyuki Okada.
Acta medica Okayama. 2023. 77(4):347-357
Negative Prognostic Impact of High-Dose or Long-Term Corticosteroid Use in Patients with Relapsed or Refractory B-Cell Lymphoma Who Received Tisagenlecleucel.
Toshiki Terao,Wataru Kitamura,Nobuharu Fujii,Noboru Asada,Chihiro Kamoi,Kanako Fujiwara,Kaho Kondo,Chisato Matsubara,Kenta Hayashino,Keisuke Seike,Hideaki Fujiwara,Daisuke Ennishi,Hisakazu Nishimori,Keiko Fujii,Ken-Ichi Matsuoka,Yoshinobu Maeda.
Transplantation and cellular therapy. 2023. 29(9):573.e1-573.e8
Utility of Comprehensive Genomic Profiling for Precise Diagnosis of Pediatric-Type Diffuse High-Grade Glioma.
Keigo Makino,Yoshihiro Otani,Kentaro Fujii,Joji Ishida,Shuichiro Hirano,Yasuki Suruga,Kana Washio,Kenji Nishida,Hiroyuki Yanai,Shuta Tomida,Daisuke Ennishi,Isao Date.
Acta medica Okayama. 2023. 77(3):323-330
Long-term outcomes of patients with primary intestinal follicular lymphoma managed with watch-and-wait strategy.
Masaya Iwamuro,Takehiro Tanaka,Daisuke Ennishi,Kazuhiro Matsueda,Masao Yoshioka,Koji Miyahara,Chihiro Sakaguchi,Mamoru Nishimura,Teruya Nagahara,Tomohiko Mannami,Ryuta Takenaka,Shohei Oka,Masafumi Inoue,Hidetaka Takimoto,Tomoki Inaba,Sayo Kobayashi,Tatsuya Toyokawa,Hirofumi Tsugeno,Seiyuu Suzuki,Sachiko Sawada,Shouichi Tanaka,Takao Tsuzuki,Hiroyuki Okada.
Scientific reports. 2023. 13(1):5858
2022
Early initiation of low-dose gilteritinib maintenance improves posttransplant outcomes in patients with R/R FLT3mut AML.
Toshiki Terao,Ken-Ichi Matsuoka,Hiroko Ueda,Akifumi Matsumura,Chisato Matsubara,Kaho Kondo,Takumi Kondo,Hideaki Fujiwara,Noboru Asada,Daisuke Ennishi,Hisakazu Nishimori,Keiko Fujii,Nobuharu Fujii,Yoshinobu Maeda.
Blood advances. 2022. 7(5):681-686
Concordance Between Recommendations From Multidisciplinary Molecular Tumor Boards and Central Consensus for Cancer Treatment in Japan.
Yoichi Naito,Kuniko Sunami,Hidenori Kage,Keigo Komine,Toraji Amano,Mitsuho Imai,Takafumi Koyama,Daisuke Ennishi,Masashi Kanai,Hirotsugu Kenmotsu,Takahiro Maeda,Sachi Morita,Daisuke Sakai,Kousuke Watanabe,Hidekazu Shirota,Ichiro Kinoshita,Masashiro Yoshioka,Nobuaki Mamesaya,Mamoru Ito,Shinji Kohsaka,Yusuke Saigusa,Kouji Yamamoto,Makoto Hirata,Katsuya Tsuchihara,Takayuki Yoshino.
JAMA Network Open. 2022. 5(12):e2245081
Zandelisib (ME-401) in Japanese patients with relapsed or refractory indolent non-Hodgkin's lymphoma: an open-label, multicenter, dose-escalation phase 1 study.
Hideki Goto,Koji Izutsu,Daisuke Ennishi,Yuko Mishima,Shinichi Makita,Koji Kato,Miyoko Hanaya,Satoshi Hirano,Kazuya Narushima,Takanori Teshima,Hirokazu Nagai,Kenichi Ishizawa.
International journal of hematology. 2022. 116(6):911-921
Expert panel consensus recommendations on the use of circulating tumor
Mitsuho Imai,Yoshiaki Nakamura,Kuniko Sunami,Hidenori Kage,Keigo Komine,Takafumi Koyama,Toraji Amano,Daisuke Ennishi,Masashi Kanai,Hirotsugu Kenmotsu,Takahiro Maeda,Sachi Morita,Daisuke Sakai,Hideaki Bando,Akitaka Makiyama,Tatsuya Suzuki,Makoto Hirata,Shinji Kohsaka,Katsuya Tsuchihara,Yoichi Naito,Takayuki Yoshino.
Cancer Science. 2022. 113(11):3646-3656
Chronological improvement in precision oncology implementation in Japan.
Kuniko Sunami,Yoichi Naito,Keigo Komine,Toraji Amano,Daisuke Ennishi,Mitsuho Imai,Hidenori Kage,Masashi Kanai,Hirotsugu Kenmotsu,Takafumi Koyama,Takahiro Maeda,Sachi Morita,Daisuke Sakai,Shinji Kohsaka,Katsuya Tsuchihara,Yusuke Saigusa,Takayuki Yoshino.
Cancer Science. 2022. 113(11):3995-4000
Establishment of a reference single-cell RNA sequencing dataset for human pancreatic adenocarcinoma.
Ryota Chijimatsu,Shogo Kobayashi,Yu Takeda,Masatoshi Kitakaze,Shotaro Tatekawa,Yasuko Arao,Mika Nakayama,Naohiro Tachibana,Taku Saito,Daisuke Ennishi,Shuta Tomida,Kazuki Sasaki,Daisaku Yamada,Yoshito Tomimaru,Hidenori Takahashi,Daisuke Okuzaki,Daisuke Motooka,Takahito Ohshiro,Masateru Taniguchi,Yutaka Suzuki,Kazuhiko Ogawa,Masaki Mori,Yuichiro Doki,Hidetoshi Eguchi,Hideshi Ishii.
iScience. 2022. 25(8):104659
Higher incidence of thrombocytopenia during obinutuzumab plus bendamustine therapy for untreated follicular lymphoma: a retrospective analysis by the Okayama Hematology Study Group.
Yuki Fujiwara,Tomohiro Urata,Daigo Niiya,Tomofumi Yano,Yuichiro Nawa,Isao Yoshida,Toshi Imai,Kazutaka Sunami,Soichiro Fujii,Daisuke Ennishi,Yoshinobu Maeda,Yasushi Hiramatsu.
International journal of hematology. 2022. 115(6):811-815
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The Journal of clinical investigation. 2022. 132(10):e145343
Sequential Combination of FLAM and Venetoclax plus Azacitidine to Bridge to Cord Blood Transplantation in a Patient with Primary Induction Failure Acute Myeloid Leukemia.
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Case reports in oncology. 2022. 15(3):974-979
Response to entrectinib in a malignant glioneuronal tumor with ARHGEF2-NTRK fusion.
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Neuro-Oncology Advances. 2022. 4(1):vdac094
Genomic Profiling of a Case of Glioneuronal Tumor with Neuropil-like Islands.
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